How To Eat 192.57 Fewer Calories and Lose 20lbs of Fat With No Effort! The Intranasal Insulin Diet Part 1
“I have used intranasal insulin to basically cure my long-term insulin resistance. My appetite has gone from extreme to barely noticeable. It feels like my brain is out of jail and free to think about other things.”
-Groundhog Day (Longecity.com member)
This post is just for the gentlemen out there (sorry ladies, I’ll write one for you soon!).
If you’ve ever wanted to eat less and lose fat with no effort then here’s how science says you can do it: take 160IU of intranasal insulin 80 minutes before a meal. R
Why do I think this will work?
Because it’s been scientifically tested.
Let’s take a look…
Note: I’ve written about how to buy intranasal insulin legally over the counter without a prescription and make it at home for $25 here: How To Make Intranasal Insulin.
Test Yourself Before You Wreck Yourself
Let’s hear it directly from the scientists who’ve studied it first-hand, “insulin treatment decreased food intake in men but not in women (difference to placebo condition, men: -192.57 +/- 78.48 kcal, P < 0.03; women: 18.54 +/- 42.89 kcal, P > 0.67).” R
Sorry ladies, it “only” significantly enhanced your memory and cognitive function in this study (which is amazing!).
I’ll write about how you can use it curb cravings and dramatically enhance brain function in a future post.
But gentleman, we are in business.
Basically, the subjects woke up, took 160IU of intranasal insulin (Actrapid) in a fasted state, and ate as much as they wanted from a buffet 80 minutes later.
And it just so happens that i-insulin made them “want” less.
192.57 calories less!
Are you bullsh$%@ing me?
The scientists concluded, “this outcome demonstrates that elevating brain insulin levels results in an immediate decrease of caloric intake in men…” R
But here’s the coolest part.
The subjects reported they felt NOTHING different.
Their hunger ratings were exactly the same on i-insulin and on placebo.
They didn’t even know they ate less.
They just did!
This is pretty astounding.
It’s not like they had more willpower, were able to overcome cravings, or had a greater ability to suffer through hunger…when it came time for breakfast they simply ate less.
I-insulin just turned off their desire for more food.
That’s pretty freaking cool if you ask me!
Has this been tested any other time?
Now, 160IU is a little high for my taste even though, “none of the subjects reported adverse side effects.” R
I still prefer minimum effective dosing.
Have any other doses been tested?
Yes they have.
40IU of intranasal insulin 100 minutes before eating reduced caloric intake in men by 168.74 calories! R
Scientists, take it away, “compared with the placebo condition, insulin significantly reduced total calorie consumption by 11.7% (168.74 ± 54.33 kcal [95% CI −258.27 to −52.20]; P = 0.008; Fig. 3A).” R
Once again, the men in this study didn’t even know they ate less…they just did.
They woke up, took 40IU of intranasal insulin in a fasted state, and were allowed to eat as much as they wanted from a buffet 100 minutes later.
The men simply “wanted” 168.74 fewer calories.
No willpower required.
Just like before, the scientists were SO surprised at this finding they hypothesized that, “hunger ratings remained unaffected by intranasal insulin application in this context, suggesting that the suppressive effects of insulin on food intake occur at an unconscious behavioral level.” R
Yup, you read that right.
Let’s hear the best part again, “the suppressive effects of insulin on food intake occur at an unconscious behavioral level.”
You can tap into your unconscious to eat less with i-insulin!
Let that sink in for second.
That’s freaking cool.
No wait, that’s cooler than cool.
That’s ICE COLD!
It’s also important note that this was just for one meal.
What would happen if I took intranasal insulin before every meal?
Could i-insulin actually help me lose weight?
Hell to the yeah!
It’s time to get this party started.
A Losing We Will Go
Not only does i-insulin reduce food intake in men, it’s also been shown to cause weight loss.
And not just ANY weight.
“Here we report the effects of 8 weeks of intranasal administration of insulin (4 x 40 IU/day) or placebo to two groups of healthy human subjects (12 men and 8 women in each group). The insulin-treated men lost 1.28 kg body wt and 1.38 kg of body fat, and their waist circumference decreased by 1.63 cm.” R
The men took 40IU of intranasal insulin 4x per day: 30 minutes before each meal and right before bed.
This caused 1.38 kg of fat loss AND decreased waist circumference by 1.63 cm in 8 weeks.
Do those amounts sound as small as Trump’s tiny hands?
Let the numbers be our guide.
How Many “8 Weeks” Are There In A Year?
This study took place over 8 weeks but, as most of us not named Kardashian know, there are 52 weeks in a year.
Divide 52 by 8 to get the number of 8 week segments in a year.
52 divided by 8 = 6.5.
So, 8 weeks happens 6.5 times per year.
The study indicates that you could lose 1.38 kg of body fat in 8 weeks.
So, how much fat would that be if we did it 6.5 times?
1.38 kg equals 3.042 lbs every 8 weeks.
Multiply 3.042 lbs by 6.5 eight week segments and you could lose 19.77 lbs of fat in a year!
That’s 20 lbs of fat loss from doing nothing!!!
Except taking intranasal insulin, of course. =)
What about waist circumference?
Have Your Pi And Eat It Too
The men lost 1.63 cm from their waists in 8 weeks.
Again, sounds kinda small.
But it ain’t.
Hit me baby 6.5 more times.
Multiply 1.63 cm by 6.5 and you get 10.595 cm which equals 4.2 inches!
Ummm…did I calculate that right?
You could lose 20 lbs of fat and 4.2 inches off your waist in one year just by taking intranasal insulin.
I love you, scientists!
High fives all around.
Let’s Wrap This Up
So, we’ve learned a few fascinating things from our scientific friends:
1) 160IU of intranasal insulin subconsciously causes us (men) to eat 192.57 calories less.
2) 40IU of intranasal insulin causes us to eat 168.74 calories less.
3) 40IU of intranasal insulin before each meal and before bed can help us lose 20lbs of fat AND 4.2 inches from our waistlines in one year.
That’s quite a series of incredible statements.
How do we apply this in our own self experiments?
I’m a big believer in minimum effective dosing because it saves us money AND minimizes our risk of side effects.
Two things we definitely want to do.
My humble suggestion is this: If your goal is to lose weight then take 10IU 4x per day…30 minutes before each meal and before bed.
Each spray of intranasal insulin is about 10IU so that would be one spray four times per day.
Novolin R costs $25 for 1000IU.
So, if you have 1000IU and take 40IU per day that would last you (1000 divided by 40) 25 days.
At $25 that would cost just one dollar per day.
Pretty darn reasonable.
Try that and if it works well for you then there is no need to spend more.
If it works, it works!
I have about 13.7 billion more things to say about how all of the mechanisms behind this function.
Especially this fundamental postulate of The Intranasal Insulin Diet: as brain energy goes up, food intake goes down (see the abstracts listed below for more info).
I’ve spent the past 5 years obsessively focused on enhancing brain energy levels so I have a few things to say on the subject. =)
Here’s a small hint.
I’ll certainly be discussing this in much greater detail in future posts.
Until then, be safe, try intranasal insulin out, and let me know how it works for you!
Note: This post was written under the influence of i-insulin, concentrated oxygen, a vibration plate, and bright light therapy. Good times!
Where To Buy
Novolin R can be purcahsed legally over the counter without a prescription at Walmart for $25.
Diabetes. 2012 Sep;61(9):2261-8. doi: 10.2337/db12-0025. Epub 2012 May 14.
Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans.
Jauch-Chara K1, Friedrich A, Rezmer M, Melchert UH, G Scholand-Engler H, Hallschmid M, Oltmanns KM.
Cerebral insulin exerts anorexic effects in humans and animals. The underlying mechanisms, however, are not clear. Because insulin physiologically facilitates glucose uptake by most tissues of the body and thereby fosters intracellular energy supply, we hypothesized that intranasal insulin reduces food consumption via enhancement of the neuroenergetic level. In a double-blind, placebo-controlled, within-subject comparison, 15 healthy men (BMI 22.2 ± 0.37 kg/m(2)) aged 22-28 years were intranasally administered insulin (40 IU) or placebo after an overnight fast. Cerebral energy metabolism was assessed by (31)P magnetic resonance spectroscopy. At 100 min after spray administration, participants consumed ad libitum from a test buffet. Our data show that intranasal insulin increases brain energy (i.e., adenosine triphosphate and phosphocreatine levels). Cerebral energy content correlates inversely with subsequent calorie intake in the control condition. Moreover, the neuroenergetic rise upon insulin administration correlates with the consecutive reduction in free-choice calorie consumption. Brain energy levels may therefore constitute a predictive value for food intake. Given that the brain synchronizes food intake behavior in dependence of its current energetic status, a future challenge in obesity treatment may be to therapeutically influence cerebral energy homeostasis. Intranasal insulin, after optimizing its application schema, seems a promising option in this regard.
J Clin Endocrinol Metab. 2008 Apr;93(4):1339-44. doi: 10.1210/jc.2007-2606. Epub 2008 Jan 29.
Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin.
Benedict C1, Kern W, Schultes B, Born J, Hallschmid M.
Brain insulin is critically involved in the regulation of body weight and memory processing. Long-term administration of intranasal insulin reduces body weight in men, but not in women, while improving hippocampus-dependent memory processing in both genders.
Our objectives were to assess the effects of a single dose of intranasal insulin on food intake and memory function in men and women, and to determine any gender differences.
A total of 32 healthy, normal-weight subjects (14 men, 18 women) were intranasally administered 160 IU regular human insulin or vehicle before performing a hippocampus-dependent two-dimensional-object location task, a working memory task (digit span), and a hippocampus-independent mirror tracing task. Subsequently, food intake from an ad libitum breakfast buffet was measured.
Insulin treatment decreased food intake in men but not in women (difference to placebo condition, men: -192.57 +/- 78.48 kcal, P < 0.03; women: 18.54 +/- 42.89 kcal, P > 0.67). In contrast, hippocampus-dependent memory and working memory were improved in women (P < 0.03, P < 0.05, respectively), whereas men did not benefit from acute insulin treatment (P > 0.17, P > 0.20). Performance on the hippocampus-independent mirror tracing task was not affected by insulin in women or men.
In accordance with animal data, results indicate that men are more sensitive than women to the acute anorexigenic effect of central nervous insulin signaling, whereas insulin’s beneficial effect on hippocampus-dependent memory functions is more pronounced in women. Our findings provide support for the notion of a fundamental gender difference in central nervous insulin signaling that pertains to the regulation of energy homeostasis and memory functions.
Diabetes. 2004 Nov;53(11):3024-9.
Intranasal insulin reduces body fat in men but not in women.
Hallschmid M1, Benedict C, Schultes B, Fehm HL, Born J, Kern W.
Insulin acts in the central nervous system to reduce food intake and body weight and is considered a major adiposity signal. After intranasal administration, insulin enters the cerebrospinal fluid compartment and alters brain functions in the absence of substantial absorption into the blood stream. Here we report the effects of 8 weeks of intranasal administration of insulin (4 x 40 IU/day) or placebo to two groups of healthy human subjects (12 men and 8 women in each group). The insulin-treated men lost 1.28 kg body wt and 1.38 kg of body fat, and their waist circumference decreased by 1.63 cm. Plasma leptin levels dropped by an average of 27%. In contrast, the insulin-treated women did not lose body fat and gained 1.04 kg body wt due to a rise in extracellular water. Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex.
J Cereb Blood Flow Metab. 2010 Jul; 30(7): 1403–1410.
Published online 2010 Apr 14. doi: 10.1038/jcbfm.2010.48
Evidence for a relationship between body mass and energy metabolism in the human brain
André Schmoller,1,* Torben Hass,1 Olga Strugovshchikova,1 Uwe H Melchert,2 Harald G Scholand-Engler,2 Achim Peters,3 Ulrich Schweiger,1 Fritz Hohagen,1 and Kerstin M Oltmanns1,4
Cerebral energy metabolism has been suggested to have an important function in body weight regulation. We therefore examined whether there is a relationship between body mass and adenosine triphosphate (ATP) metabolism in the human brain. On the basis of our earlier findings indicating a neuroprotective preferential energy supply of the brain, as compared with peripheral muscle on experimentally induced hypoglycemia, we examined whether this physiological response is preserved also in low-weight and obese participants. We included 45 healthy male subjects with a body mass index (BMI) ranging from 17 to 44 kg/m2. Each participant underwent a hypoglycemic glucose-clamp intervention, and the ATP metabolism, that is, the content of high-energy phosphates phosphocreatine (PCr) and ATP, was measured repeatedly by 31phosphor magnetic resonance spectroscopy (31P-MRS) in the cerebral cortex and skeletal muscle. Results show an inverse correlation between BMI and high-energy phosphate content in the brain (P<0.01), whereas there was no such relationship found between skeletal muscle and BMI. The hypoglycemic clamp intervention did not affect the ATP metabolism in both tissues. Our data show an inverse correlation between BMI and cerebral high-energy phosphate content in healthy humans, suggesting a close relationship between energetic supply of the brain and body weight regulation.
Diabetes. 2011 Jan;60(1):114-8. doi: 10.2337/db10-0329. Epub 2010 Sep 28.
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men.
Benedict C1, Brede S, Schiöth HB, Lehnert H, Schultes B, Born J, Hallschmid M.
Animal studies indicate a prominent role of brain insulin signaling in the regulation of peripheral energy metabolism. We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans.
RESEARCH DESIGN AND METHODS:
In a double-blind, placebo-controlled, balanced within-subject comparison, 19 healthy normal-weight men (18-26 years old) were intranasally administered 160 IU human insulin after an overnight fast. Energy expenditure assessed via indirect calorimetry and blood concentrations of glucose, insulin, C-peptide, and free fatty acids (FFAs) were measured before and after insulin administration and the subsequent consumption of a high-calorie liquid meal of 900 kcal.
Intranasal insulin, compared with placebo, increased postprandial energy expenditure, i.e., diet-induced thermogenesis, and decreased postprandial concentrations of circulating insulin and C-peptide, whereas postprandial plasma glucose concentrations did not differ from placebo values. Intranasal insulin also induced a transient decrease in prandial serum FFA levels.
Enhancing brain insulin signaling by means of intranasal insulin administration enhances the acute thermoregulatory and glucoregulatory response to food intake, suggesting that central nervous insulin contributes to the control of whole-body energy homeostasis in humans.
Diabetes. 2014 Dec;63(12):4083-8. doi: 10.2337/db14-0477. Epub 2014 Jul 15.
Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men.
Heni M1, Wagner R2, Kullmann S3, Veit R4, Mat Husin H5, Linder K1, Benkendorff C6, Peter A1, Stefan N1, Häring HU1, Preissl H3, Fritsche A1.
Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulin sensitivity and the mechanisms involved in this process. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic glucose clamp before and after intranasal application of insulin and placebo in randomized order in lean and obese men. After insulin spray application in lean subjects, a higher glucose infusion rate was necessary to maintain euglycemia compared with placebo. Accordingly, clamp-derived insulin sensitivity index improved after insulin spray. In obese subjects, this insulin-sensitizing effect could not be detected. Change in the high-frequency band of heart rate variability, an estimate of parasympathetic output, correlated positively with change in whole-body insulin sensitivity after intranasal insulin. Improvement in whole-body insulin sensitivity correlated with the change in hypothalamic activity as assessed by functional magnetic resonance imaging. Intranasal insulin improves peripheral insulin sensitivity in lean but not in obese men. Furthermore, brain-derived peripheral insulinsensitization is associated with hypothalamic activity and parasympathetic outputs. Thus, the findings provide novel insights into the regulation of insulin sensitivity and the pathogenesis of insulin resistance in humans.